Hypotension Research Today is a free monthly online journal that collates and summarizes the latest research about Hypotension, including details on low blood pressure, blood volume, symptoms, treatment.

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic-type tinea pedis.

Kikuchi I, Tanuma H, Morimoto K, Kawana S

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

To study and establish an optimal administration method of oral antifungal, terbinafine (TBF), for hyperkeratotic-type tinea pedis from the pharmacokinetic point of view, 20 patients with hyperkeratotic-type tinea pedis were given TBF 125 mg once daily for 4 weeks and observed over time for improvement of dermatological symptoms and mycological efficacy. Targeting five of the patients, TBF concentration in the stratum corneum was measured using the LC-MS/MS method. TBF was detected in the stratum corneum of the sole 1 week after beginning the treatment in some cases and reached its peak 1 week after the completion of the treatment with a concentration of 247.8 ng g(-1), which was approximately more than 50 times higher than its minimal inhibitory concentration against dermatophytes. TBF was not detected at 8 weeks post-treatment, although its concentration was 50.73 ng g(-1) at 6 weeks post-treatment. All cases were subjected to analysis for final total efficacy, general safety and usefulness. Its effectiveness rate (effective + markedly effective) was 95% (19/20) with no adverse reactions, including abnormal changes in the laboratory test values, in any patients. From the above, it is noted that TBF showed excellent efficacy and safety for refractory hyperkeratotic-type tinea pedis, and also it was considered as a useful drug to treat cutaneous mycosis, including hyperkeratotic-type tinea pedis, from the pharmacokinetic point of view.

Published 21 April 2008 in Mycoses.
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Articles on Hypotension published 21 April 2008:

Tinea capitis among primary school children in some parts of central Nigeria.   Mycoses.

Tinea capitis is the most common superficial mycosis in children of school age. Although it is of public health importance, it is not a reportable or notifiable disease; therefore, actual prevalence figures are unknown in many endemic areas. The aim of this work was to determine the prevalence of tinea capitis among primary school children in two states in central Nigeria, highlighting the main aetiological agents of the infection and possible predisposing factors. A total of 28 505 primary ... [Abstract] [Full-text]

Trichophyton rubrum autoinoculation from infected nails is not such a rare phenomenon.   Mycoses.

Kerion-like lesions are usually caused by zoophilic dermatophytes. Here, we present a rare case report - an inflammatory tinea barbae due to an anthropophilic fungus (Trichophyton rubrum), which is the main pathogen of onychomycosis and tinea pedis. Probably the infection, in the presented case, spread from diseased fingernails. We do postulate that physicians should consider autoinoculation as a not so rare way of fungal infection transmission. [Abstract] [Full-text]

Preanalytical conditions for broth microdilution antifungal susceptibility of Microsporum spp.   Mycoses.

Dermatophytoses caused by the genus Microsporum require a long-duration therapy compared to infections caused by other genera. Treatment of these cutaneous infections includes topical and systemic antifungal agents. Tinea capitis and tinea unguium caused by M. canis and M. gypseum are the most difficult-to-treat dermatophytoses. There are few specific studies about corresponding antifungal susceptibility in vitro. Recently, the Clinical and Laboratory Standards Institute proposed the M38A ... [Abstract] [Full-text]

Widespread, chronic, and fluconazole-resistant Trichophyton rubrum infection in an immunocompetent patient.   Mycoses.

Chronic, widespread and invasive cutaneous dermatophytoses due to Trichopyhton rubrum are common in immunocompromised patients. In immunocompetent individuals, however, chronic widespread dermatophytoses are more often associated with onychomycosis and tinea pedis. We describe a 54-year-old immunocompetent female who presented with a 2-year history of extensive erythematous and hyper-pigmented scaly plaques involving the abdominal, gluteal and crural regions without concomitant tinea pedis, ... [Abstract] [Full-text]

Tinea capitis among primary school children in Anambra state of Nigeria.   Mycoses.

Tinea capitis continues to be a common problem of infancy and childhood, particularly among those living in unhygienic crowded conditions. The prevalence and aetiology of tinea capitis have not been well defined in Anambra state of Nigeria - hence the need to undertake this study. A total of 47 723 primary school children residing in different regions of the State was screened for tinea capitis between 2002 and 2005. Of this number, 4498 (9.4%) had tinea capitis. The highest prevalence of the ... [Abstract] [Full-text]

Articles on Hypotension published 11 April 2008:

Examining Trichophyton tonsurans genotype and biochemical phenotype as determinants of disease severity in tinea capitis.   Med Mycol, 46(3): 217-23.

Trichophyton tonsurans infections occur in various host populations, on various body sites and with varying degrees of inflammation. This investigation was undertaken to determine whether fungal factors could explain the degree of severity in clinical symptomatology among infected children. Otherwise healthy children (n=54) presenting with tinea capitis were enrolled in this study. A thorough history was performed, the extent and severity of infection graded and a fungal specimen collected from ... [Abstract] [Full-text]

Articles on Hypotension published 8 April 2008:

High-frequency intragenomic heterogeneity of the ribosomal DNA intergenic spacer region in Trichophyton violaceum.   Eukaryot Cell, 7(4): 721-6.

The intergenic spacer (IGS) of the rRNA genes was analyzed from the dermatophyte Trichophyton violaceum isolated from cases of tinea capitis in Taiwan and Iran. T. violaceum strains were cultured from different colonies, from single conidial colonies derived by dilution plating, and from micromanipulation of single conidia from clinical samples. A ribosomal DNA probe hybridizing to multiple EcoRI fragments was used to compare restriction fragment length polymorphisms in different T. violaceum ... [Abstract] [Full-text]

Articles on Hypotension published 1 April 2008:

Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: Results of two randomized, investigator-blinded, multicenter, international, controlled trials.   J Am Acad Dermatol.

BACKGROUND: Although griseofulvin is currently considered the primary antifungal agent used to treat tinea capitis in many countries, increasingly higher doses and longer durations of treatment are becoming necessary to achieve effective treatment. Alternative antifungal therapies with shorter/simpler treatment regimens may be important to develop for this indication. OBJECTIVE: To compare the efficacy and safety of a new pediatric formulation of terbinafine hydrochloride oral granules with ... [Abstract] [Full-text]

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